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Ajmalicine (Raubasine)

Cat. No. M10654
Ajmalicine (Raubasine) Structure
Synonym:

Raubasine

Size Price Availability Quantity
1mg USD 200  USD200 In stock
2mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

Ajmalicine (Raubasine) is an adrenolytic agent which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor. Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM. Ajmalicine (Raubasine) acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.

Chemical Information
Molecular Weight 352.43
Formula C21H24N2O3
CAS Number 483-04-5
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tengfei Liu, et al. Biotechnol Bioeng. Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast

[2] Shu Liu, et al. Curr Pharm Des. Ajmalicine and its Analogues Against AChE and BuChE for the Management of Alzheimer's Disease: An In-silico Study

[3] Priya Kashyap, et al. Molecules. Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer's Disease

[4] Ghazala Ambrin, et al. Front Bioeng Biotechnol. Conversion of Cytochrome P450 2D6 of Human Into a FRET-Based Tool for Real-Time Monitoring of Ajmalicine in Living Cells

[5] Kai Chang, et al. Biotechnol Appl Biochem. Engineering the MEP pathway enhanced ajmalicine biosynthesis

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