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Ajmalicine (Raubasine)

Cat. No. M10654
Ajmalicine (Raubasine) Structure
Synonym:

Raubasine

Size Price Availability Quantity
1mg USD 200  USD200 In stock
2mg USD 350  USD350 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ajmalicine (Raubasine) is an adrenolytic agent which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor. Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM. Ajmalicine (Raubasine) acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 352.43
Formula C21H24N2O3
CAS Number 483-04-5
Purity >98%
Solubility
Storage 2-8°C, dry, sealed
References

[1] Tengfei Liu, et al. Biotechnol Bioeng. Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast

[2] Shu Liu, et al. Curr Pharm Des. Ajmalicine and its Analogues Against AChE and BuChE for the Management of Alzheimer's Disease: An In-silico Study

[3] Priya Kashyap, et al. Molecules. Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer's Disease

[4] Ghazala Ambrin, et al. Front Bioeng Biotechnol. Conversion of Cytochrome P450 2D6 of Human Into a FRET-Based Tool for Real-Time Monitoring of Ajmalicine in Living Cells

[5] Kai Chang, et al. Biotechnol Appl Biochem. Engineering the MEP pathway enhanced ajmalicine biosynthesis

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