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Ranitidine HCl

Cat. No. M5921
Ranitidine HCl Structure
Synonym:

AH19065

Size Price Availability Quantity
50mg USD 60  USD60 In stock
100mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.

Chemical Information
Molecular Weight 350.86
Formula C13H22N4O3S.HCl
CAS Number 66357-59-3
Solubility (25°C) 70 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Johansson S. et al. Clin Pharmacokinet. Pharmacokinetic evaluations of the co-administrations of vandetanib and metformin, digoxin, midazolam, omeprazole or ranitidine.

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Keywords: Ranitidine HCl, AH19065 supplier, Histamine Receptor, inhibitors, activators


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