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Ranitidine HCl

Cat. No. M5921
Ranitidine HCl Structure
Synonym:

AH19065

Size Price Availability Quantity
50mg USD 60 In stock
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 350.86
Formula C13H22N4O3S.HCl
CAS Number 66357-59-3
Purity >99%
Solubility 70 mg/mL in DMSO
Storage at -20°C
References

Pharmacokinetic evaluations of the co-administrations of vandetanib and metformin, digoxin, midazolam, omeprazole or ranitidine.
Johansson S. et al. Clin Pharmacokinet. 2014 Sep;53(9):837-47. PMID: 25117183.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ranitidine HCl, AH19065 supplier, Histamine Receptor, inhibitors

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