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Raloxifene HCl

Cat. No. M5917
Raloxifene HCl Structure
Synonym:

LY156758 hydrochloride

Size Price Availability Quantity
50mg USD 54  USD60 In stock
100mg USD 90  USD100 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 510.04
Formula C28H28ClNO4S
CAS Number 82640-04-8
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Comparative cost-effectiveness of bazedoxifene and raloxifene in the treatment of postmenopausal osteoporosis in Europe, using the FRAX algorithm.
Kim K, et al. Osteoporos Int. 2014 Jan;25(1):325-37. PMID: 24114398.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Raloxifene HCl, LY156758 hydrochloride supplier, Estrogen Receptor, inhibitors

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