Radicicol is a antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||ethanol 9.12 mg/mL|
Ifenprodil and SL-82,0715 as cerebral anti-ischemic agents 1 Evidence for efficacy in models of focal cerebral ischemia.
Gotti, et al. J Pharmacol Exp Ther. 1988;247: 1211. PMID: 2849668.
|all-trans 4-Keto Retinoic Acid
all-trans 4-Keto Retinoic Acid is an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
GK921 is a transglutaminase 2 (TGase 2) inhibitor.
Miridesap is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles.
Aramchol is a cholesterol solubilizer that prevents gallstone formation in inbred mice.
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