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(Rac)-Brassinazole

Cat. No. M9684
(Rac)-Brassinazole Structure
Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 175  USD175 In stock
25mg USD 290  USD290 In stock
50mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

(Rac)-Brassinazole is a brassinosteroid (BR) biosynthesis inhibitor. (Rac)-Brassinazole increases inhibition of CYP90B in BR biosynthesis.

Chemical Information
Molecular Weight 327.81
Formula C18H18ClN3O
CAS Number 224047-41-0
Solubility (25°C) DMSO
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Y K Min, et al. Bioorg Med Chem Lett. New lead compounds for brassinosteroid biosynthesis inhibitors

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Keywords: (Rac)-Brassinazole supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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