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Rabdosiin

Cat. No. M38763
Rabdosiin Structure
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Biological Activity

Rabdosiin is a tetramer of caffeic acid isolated from the stem of Ocimum sanctum. Rabdosiin possess anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.

Chemical Information
Molecular Weight 718.61
Formula C36H30O16
CAS Number 263397-69-9
Form Solid
Solubility (25°C) DMSO 90 mg/mL (ultrasonic)
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Adriana Trifan et al. Phytochem Anal. Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European-sourced comfrey (Symphytum officinale L.) root samples

[2] Alexandros Flegkas et al. Medicines (Basel). Antiproliferative Activity of (-)-Rabdosiin Isolated from Ocimum sanctum L

[3] Yuliya V Inyushkina et al. Biosci Biotechnol Biochem. High rabdosiin and rosmarinic acid production in Eritrichium sericeum callus cultures and the effect of the calli on masugi-nephritis in rats

[4] Victor P Bulgakov et al. Planta. Inhibitory effect of the Agrobacterium rhizogenes rolC gene on rabdosiin and rosmarinic acid production in Eritrichium sericeum and Lithospermum erythrorhizon transformed cell cultures

[5] H Ito et al. Bioorg Med Chem. Antiallergic activities of rabdosiin and its related compounds: chemical and biochemical evaluations

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