Quinine sulfate hydrate (2:1:4) is an orally active potassium channel inhibitor that inhibits voltage pulse-induced currents in MT mSlo3 (KCa5.1) channels +100 mV with an IC50 of 169 μM.In addition, Quinine sulfate hydrate binds to PfPNP with low nanomolar affinity. In addition, Quinine sulfatehydrate binds to purine nucleoside phosphorylase (PfPNP) with low nanomolar affinity.
| Molecular Weight | 458.53 |
| Formula | C20H30N2O8S |
| CAS Number | 6119-70-6 |
| Form | Solid |
| Storage | 4°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Dzenan Jahic et al. Mater Sociomed. Exercise-Associated Muscle Cramp-Doubts About the Cause
[5] J K Weser et al. N Engl J Med. Drug interactions with coumarin anticoagulants. 2
| Related Potassium Channel Products |
|---|
| NPBA
NPBA is a potassium K2P channel TASK-3 (KCNK9) agonist and a tandem pore domain weak inward rectifier K+ channel (TWIK2) channel blocker. In addition, NPBA inhibits the activation of NLRP3 inflammasome in macrophages. |
| BeKm-1
BeKm-1 is a HERG (human ether-a-go-go-related gene) blocking compound. |
| Apamin
Apamin (Apamine) is a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. |
| Phe-Met-Arg-Phe amide trifluoroacetate
Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons. |
| Iberiotoxin
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. |
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