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Pyrogallol

Cat. No. M17316
Pyrogallol Structure
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Biological Activity

Pyrogallol

Chemical Information
CAS Number 87-66-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Haixia Su, et al. Nat Commun. Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

[2] Dongting Yao, et al. Antimicrob Agents Chemother. Pyrogallol and Fluconazole Interact Synergistically In Vitro against Candida glabrata through an Efflux-Associated Mechanism

[3] Janaina E Rocha, et al. Environ Geochem Health. FTIR analysis of pyrogallol and phytotoxicity-reductive effect against mercury chloride

[4] Ghanshyam Upadhyay, et al. Chem Biol Interact. Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations

[5] S Marklund, et al. Eur J Biochem. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase

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