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Purvalanol B

Cat. No. M2590
Purvalanol B Structure
Synonym:

NG 95

Size Price Availability
10mM*1mL In DMSO USD 90 Out of stock
10mg USD 145 Out of stock
50mg USD 540 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Purvalanol B is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.Purvalanol B is Selective over a range of other protein kinases (IC50 > 10,000 nM).It Shown to have antiproliferative properties, mediated by p42/p44 MAPK. Purvalanol inhibited the nuclear accumulation of p42/p44 MAPK, an event dependent on the catalytic activity of these kinases .

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 432.91
Formula C20H25ClN6O3
CAS Number 212844-54-7
Purity >98%
Solubility DMSO
Storage at -20°C
References

p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
Knockaert M,et al. Oncogene. 2002 Sep 19;21(42):6413-24. PMID: 12226745.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Purvalanol B, NG 95 supplier, CDK, inhibitors

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