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Psora 4

Cat. No. M7172

All AbMole products are for research use only, cannot be used for human consumption.

Psora 4 Structure

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Quality Control & Documentation
Biological Activity

Psora 4 is a potent KV1.3 channel blocker (EC50 = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818. Displays 17- to 70-fold selectivity over closely-related KV1 channels (KV1, KV2, KV4 and KV7); exhibits activity at KV1.5 (IC50 = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC50 values are 25 and 60 nM respectively).

Chemical Information
Molecular Weight 334.37
Formula C21H18O4
CAS Number 724709-68-6
Solubility (25°C) DMSO 16.72 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Murza, et al. J Med Chem. Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions.

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