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Psidial A

Cat. No. M17593
Psidial A Structure
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Biological Activity

Psidial A

Chemical Information
CAS Number 1207181-35-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jaqueline Moraes Bazioli, et al. Molecules. Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves ( Psidium guajava L.)

[2] L Y Rizzo, et al. Curr Med Chem. In vitro, in vivo and in silico analysis of the anticancer and estrogen-like activity of guava leaf extracts

[3] Meng Shao, et al. Org Lett. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava

[4] Andrew L Lawrence, et al. Org Lett. A short biomimetic synthesis of the meroterpenoids guajadial and psidial A

[5] Hui-Zheng Fu, et al. Org Lett. Psidials A-C, three unusual meroterpenoids from the leaves of Psidium guajava L

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