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Cedrol

Cat. No. M17603
Cedrol Structure
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Biological Activity

Cedrol

Chemical Information
CAS Number 77-53-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gulmira zek, et al. Molecules. Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species

[2] Wangchao Dong, et al. In Vitro Cell Dev Biol Anim. Cedrol alleviates the apoptosis and inflammatory response of IL-1β-treated chondrocytes by promoting miR-542-5p expression

[3] Kai-Fu Chang, et al. Cancer Lett. Cedrol suppresses glioblastoma progression by triggering DNA damage and blocking nuclear translocation of the androgen receptor

[4] Kai-Fu Chang, et al. J Nat Prod. Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression

[5] Mohammad Hossein Sakhaee, et al. Metab Brain Dis. Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation

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