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Protosappanin A

Cat. No. M10696
Protosappanin A Structure
Synonym:

原苏木素A; PTA

Size Price Availability Quantity
1mg USD 148  USD185 In stock
5mg USD 432  USD540 In stock
10mg USD 688  USD860 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Protosappanin A (PTA), an immune agent, is a major biphenyl compound isolated from Caesalpinia sappan L that inhibits the JAK2/STAT3-dependent inflammatory pathway by down-regulating the phosphorylation of JAK2 and STAT3.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 272.25
Formula C15H12O5
CAS Number 102036-28-2
Purity >99%
Solubility DMSO ≥ 200 mg/mL
Storage 4°C protect from light dry
References

[1] Li-Xi Liao, et al. ACS Chem Neurosci. Protosappanin A Maintains Neuronal Mitochondrial Homeostasis through Promoting Autophagic Degradation of Bax

[2] Qiang Huang, et al. Int J Clin Exp Pathol. Protosappanin a inhibits osteoclastogenesis via reducing oxidative stress in RAW264.7 cells

[3] Jian Wu, et al. Pharmacol Res. Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs

[4] Li-Chao Wang, et al. Chin J Nat Med. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia

[5] Jian Wu, et al. Naunyn Schmiedebergs Arch Pharmacol. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway

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Keywords: Protosappanin A, 原苏木素A; PTA supplier, JAK, inhibitors

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