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Propofol

Cat. No. M6195
Propofol Structure
Size Price Availability Quantity
100mg USD 90 In stock
500mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In present study, we found propofol markedly decreased the HOTAIR expression of cervical cancer cells in a dose-dependent manner. In vitro experiments, we found HOTAIR overexpression promoted cervical carcinoma cells growth and inhibited cell apoptosis after the treatment of propofol.

Protocol
Cell Experiment
Cell lines Caski cells
Preparation method 1 × 10^4 cells/well HeLa, CaSki and C33A cells were plated incubated in 96-well culture plates at 37℃ for 24 h, and then co-cultured with different concentrations (0 μg/ml, 1 μg/ml, 5 μg/ml and 10 μg/ml) of propofol for another 48 h.
Concentrations 10 μg/ml
Incubation time 48 h
Animal Experiment
Animal models C57BL/6 mice
Formulation soybean oil
Dosages 50 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 178.27
Formula C12H18O
CAS Number 2078-54-8
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Propofol promotes cell apoptosis via inhibiting HOTAIR mediated mTOR pathway in cervical cancer.
Zhang D, et al. Biochem Biophys Res Commun. 2015 Dec 25;468(4):561-7. PMID: 26523512.

Down-regulation of microRNA-21 is involved in the propofol-induced neurotoxicity observed in human stem cell-derived neurons.
Twaroski DM, et al. Anesthesiology. 2014 Oct;121(4):786-800. PMID: 24950164.

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  Catalog
Abmole Inhibitor Catalog 2017




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