Free shipping on all orders over $ 500


Cat. No. M6195
Propofol Structure


Size Price Availability Quantity
1mL USD 120  USD120 In stock
5mL USD 240  USD240 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In present study, we found propofol markedly decreased the HOTAIR expression of cervical cancer cells in a dose-dependent manner. In vitro experiments, we found HOTAIR overexpression promoted cervical carcinoma cells growth and inhibited cell apoptosis after the treatment of propofol.

Cell Experiment
Cell lines Caski cells
Preparation method 1 × 10^4 cells/well HeLa, CaSki and C33A cells were plated incubated in 96-well culture plates at 37℃ for 24 h, and then co-cultured with different concentrations (0 μg/ml, 1 μg/ml, 5 μg/ml and 10 μg/ml) of propofol for another 48 h.
Concentrations 10 μg/ml
Incubation time 48 h
Animal Experiment
Animal models C57BL/6 mice
Formulation soybean oil
Dosages 50 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 178.27
Formula C12H18O
CAS Number 2078-54-8
Purity >99%
Solubility DMSO ≥ 30 mg/mL
Storage 2-8°C, sealed

[1] Zhang D, et al. Biochem Biophys Res Commun. Propofol promotes cell apoptosis via inhibiting HOTAIR mediated mTOR pathway in cervical cancer.

[2] Twaroski DM, et al. Anesthesiology. Down-regulation of microRNA-21 is involved in the propofol-induced neurotoxicity observed in human stem cell-derived neurons.

Related GABA Receptor Products

Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors.

SSD114 hydrochloride

SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.


Pipequaline (PK-8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.


AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.


ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models.

Abmole Inhibitor Catalog 2017

Keywords: Propofol, 2,6-Diisopropylphenol supplier, GABA Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.