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Proparacaine HCl

Cat. No. M5904
Proparacaine HCl Structure
Synonym:

Proxymetacaine Hydrochloride

Size Price Availability Quantity
50mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 330.85
Formula C16H26N2O3.HCl
CAS Number 5875-06-9
Purity >98%
Solubility 66 mg/mL in water
Storage at -20°C
References

Cytotoxicity of proparacaine to human corneal endothelial cells in vitro.
Wen Q, et al. J Toxicol Sci. 2015 Aug;40(4):427-36. PMID: 26165639.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Proparacaine HCl, Proxymetacaine Hydrochloride supplier, Sodium Channel, inhibitors

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