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Procyanidin A2

Cat. No. M16711
Procyanidin A2 Structure
Size Price Availability Quantity
5mg USD 260  USD260 In stock
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Quality Control & Documentation
Biological Activity

Procyanidin A2 is a flavonoid with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity, found in grapes, cranberries and lingonberries.

Chemical Information
Molecular Weight 576.50
Formula C30H24O12
CAS Number 41743-41-3
Solubility (25°C) DMSO 90 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yunush Sheikh, et al. RSC Adv. Procyanidin A2, an anti-diabetic condensed tannin extracted from Wendlandia glabrata, reduces elevated G-6-Pase and mRNA levels in diabetic mice and increases glucose uptake in CC1 hepatocytes and C1C12 myoblast cells

[2] Shiying Yang, et al. J Agric Food Chem. Gut Microbiota Composition Affects Procyanidin A2-Attenuated Atherosclerosis in ApoE -/- Mice by Modulating the Bioavailability of Its Microbial Metabolites

[3] Qin-Qin Wang, et al. PLoS One. Procyanidin A2, a polyphenolic compound, exerts anti-inflammatory and anti-oxidative activity in lipopolysaccharide-stimulated RAW264.7 cells

[4] Cdric De Taeye, et al. J Agric Food Chem. Procyanidin A2 and Its Degradation Products in Raw, Fermented, and Roasted Cocoa

[5] Sara L Coleman, et al. Int J Mol Sci. Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells

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