Free shipping on all orders over $ 500

Prilocaine

Cat. No. M5897
Prilocaine Structure
Synonym:

NSC 40027

Size Price Availability Quantity
50mg USD 90 In stock
100mg USD 140 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 220.31
Formula C13H20N2O
CAS Number 721-50-6
Purity >98%
Solubility 44 mg/mL in DMSO
Storage at -20°C
References

Methemoglobinemia induced by lidocaine-prilocaine cream.
Shamriz O, et al. Isr Med Assoc J. 2014 Apr;16(4):250-4. PMID: 24834764.

Related Sodium Channel Products
GNE-131

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.

PF-06869206

PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.

Eleclazine hydrochloride

Eleclazine HCl is a novel late Na+ current inhibitor, with IC50 value of 0.7 uM.

Levobupivacaine

Levobupivacaine is a reversible neuronal sodium channel inhibitor.

PF-05089771

PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Prilocaine, NSC 40027 supplier, Sodium Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.