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Prilocaine

Cat. No. M5897
Prilocaine Structure
Synonym:

NSC 40027

Size Price Availability Quantity
50mg USD 90 In stock
100mg USD 140 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 220.31
Formula C13H20N2O
CAS Number 721-50-6
Purity >99%
Solubility 44 mg/mL in DMSO
Storage at -20°C
References

Methemoglobinemia induced by lidocaine-prilocaine cream.
Shamriz O, et al. Isr Med Assoc J. 2014 Apr;16(4):250-4. PMID: 24834764.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Prilocaine, NSC 40027 supplier, Sodium Channel, inhibitors

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