Pregnenolone (3β -hydroxy-5-pregnen-20-one) is a powerful neurosteroid, and is the major precursor of various steroids, including steroids. Pregnenolone is a signal-transduction specific inhibitor of cannabinoid CB1 receptor, which inhibits the effects of THC mediated by CB1 receptor. Pregnenolone protects the brain against cannabis intoxication. Pregnenolone is also a TRPM3 pathway activator, and Pregnenolone can also induce weak activation of the TRPM1 pathway.
| Molecular Weight | 316.48 |
| Formula | C21H32O2 |
| CAS Number | 145-13-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Jui-Hsia Weng, et al. Nongenomic actions of neurosteroid pregnenolone and its metabolites
[2] Monique Valle. Neurosteroids and potential therapeutics: Focus on pregnenolone
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