Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||4 mg/mL warmed in DMSO|
Comparison of terazosin and prazosin for treatment of vesico-urethral reflex dyssynergia in dogs.
Haagsman AN, et al. Vet Rec. 2013 Jul 13;173(2):41. PMID: 23784060.
|Related Adrenergic Receptor Products|
Fenoterol is a β2 adrenoreceptor agonist with bronchodilator activity.
Norepinephrine is generally considered to be a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
Vibegron is a potent and selective beta 3 adrenergic receptor agonist.
L-755,507 is a very potent and selective β3 partial agonist.
5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
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