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Prazosin HCl

Cat. No. M5895
Prazosin HCl Structure
Synonym:

cp-12299-1

Size Price Availability Quantity
100mg USD 100 In stock
500mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 419.86
Formula C19H21N5O4·HCl
CAS Number 19237-84-4
Purity >99%
Solubility 4 mg/mL warmed in DMSO
Storage at -20°C
References

Comparison of terazosin and prazosin for treatment of vesico-urethral reflex dyssynergia in dogs.
Haagsman AN, et al. Vet Rec. 2013 Jul 13;173(2):41. PMID: 23784060.

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  Catalog
Abmole Inhibitor Catalog 2017




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