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Prazosin hydrochloride

Cat. No. M5895
Prazosin hydrochloride Structure
Synonym:

cp-12299-1

Size Price Availability Quantity
50mg USD 40  USD40 In stock
100mg USD 60  USD60 In stock
500mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Prazosin hydrochloride, a Quinazoline derivative, is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM. Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively.

Chemical Information
Molecular Weight 419.86
Formula C19H21N5O4·HCl
CAS Number 19237-84-4
Solubility (25°C) DMSO 7 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Haagsman AN, et al. Vet Rec. Comparison of terazosin and prazosin for treatment of vesico-urethral reflex dyssynergia in dogs.

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