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Pralatrexate

Cat. No. M3303
Pralatrexate Structure
Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 130  USD130 In stock
25mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

Pralatrexate (Folotyn) is an antifolate, and structurally a folate analog. It acts as an inhibitor of dihydrofolate reductase. It is selective for the reduced folate carrier type 1. Its IC50 is < 300 nM in some cell lines.

Chemical Information
Molecular Weight 477.47
Formula C23H23N7O5
CAS Number 146464-95-1
Solubility (25°C) DMSO 27 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mehmet Sinan Dal, et al. Pralatrexate experience in PTCL: A multicenter retrospective study from Turkey

[2] No authors listed. Pralatrexate

[3] No authors listed. Aust Prescr. Pralatrexate for lymphoma

[4] Gary S Wood, et al. Methotrexate and Pralatrexate

[5] Owen A O'Connor, et al. Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL study

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Keywords: Pralatrexate supplier, Antifolate, inhibitors, activators


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