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Polycaprolactone

Cat. No. M9377
Polycaprolactone Structure
Synonym:

PCL

Size Price Availability Quantity
5g USD 40  USD40 In stock
25g USD 90  USD90 In stock
50g USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Chemical Information
Formula (C6H10O2)n
CAS Number 24980-41-4
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sara Liparoti, et al. Polycaprolactone/polyethylene-glycol capsules made by injection molding: A drug release modeling

[2] Nadeem Siddiqui, et al. Electropsun Polycaprolactone Fibres in Bone Tissue Engineering: A Review

[3] Mengen Zhang, et al. Oxygen-releasing polycaprolactone/calcium peroxide composite microspheres

[4] Swee-Hin Teoh, et al. Three-Dimensional Printed Polycaprolactone Scaffolds for Bone Regeneration Success and Future Perspective

[5] Marianne Labet, et al. Synthesis of polycaprolactone: a review

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Keywords: Polycaprolactone, PCL supplier, inhibitors, activators


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