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PND-1186

Cat. No. M4978
PND-1186 Structure
Synonym:

VS-4718

Size Price Availability Quantity
2mg USD 75 In stock
5mg USD 110 In stock
10mg USD 150 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In mice bearing 4T1 tumors, PND-1186 (100 mg/kg s.c.) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis. In mice bearing ID8 tumors, PND-1186 (0.5 mg/mL for p.o.) also causes ovarian carcinoma tumor growth inhibition.Addition of PND-1186 to the drinking water of mice was well tolerated and inhibited ascites- and peritoneal membrane-associated ovarian carcinoma tumor growth associated with the inhibition of FAK Tyr-397 phosphorylation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 501.5
Formula C25H26F3N5O3
CAS Number 1061353-68-1
Purity >99%
Solubility DMSO 24 mg/mL
Water <1 mg/mL
Storage at -20°C
References

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.
Tanjoni I,et.al. Cancer Biol Ther 2010 May 15;764-77. PMID: 20234191.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PND-1186, VS-4718 supplier, FAK, inhibitors

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