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Pinosylvin

Cat. No. M17317
Pinosylvin Structure
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Biological Activity

Pinosylvin

Chemical Information
CAS Number 22139-77-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Saad Bakrim, et al. Plants (Basel). Natural Sources and Pharmacological Properties of Pinosylvin

[2] Yi-Ching Chuang, et al. Oncol Rep. Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2

[3] Konsta Kivimki, et al. Molecules. Pinosylvin Shifts Macrophage Polarization to Support Resolution of Inflammation

[4] Jina Song, et al. Phytother Res. Pinosylvin enhances leukemia cell death via down-regulation of AMPKα expression

[5] Ohseong Kwon, et al. BMB Rep. Pinosylvin exacerbates LPS-induced apoptosis via ALOX 15 upregulation in leukocytes

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