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Phenytoin

Cat. No. M5875
Phenytoin Structure
Synonym:

Diphenylhydantoin

Size Price Availability Quantity
100mg USD 60 In stock
500mg USD 90 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Phenytoin is an inactive voltage-gated sodium channel stabilizer.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 252.27
Formula C15H12N2O2
CAS Number 57-41-0
Purity >98%
Solubility 50 mg/mL in DMSO
Storage at -20°C
References

CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.
Franco V, et al. Expert Opin Drug Metab Toxicol. 2015;11(8):1269-79. PMID: 26037375.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Phenytoin, Diphenylhydantoin supplier, Sodium Channel, inhibitors

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