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Penbutolol sulfate

Cat. No. M13898
Penbutolol sulfate Structure
Synonym:

(-)-Terbuclomine

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Penbutolol sulfate is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker. Penbutolol is a sympathomimetic drug,used in the treatment of high blood pressure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 340.47
Formula
CAS Number 38363-32-5
Purity >99%
Solubility Water 5 mg/mL
Storage 2-8°C, dry, sealed
References

[1] No authors listed. Penbutolol

[2] No authors listed. Beta Adrenergic Blocking Agents

[3] No authors listed. Penbutolol

[4] Kevin B Ita, et al. Influence of sonophoresis and chemical penetration enhancers on percutaneous transport of penbutolol sulfate

[5] K B Ita, et al. In vitro transdermal iontophoretic delivery of penbutolol sulfate

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Keywords: Penbutolol sulfate, (-)-Terbuclomine supplier, Adrenergic Receptor, inhibitors

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