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Penbutolol sulfate

Cat. No. M13898
Penbutolol sulfate Structure
Synonym:

(-)-Terbuclomine

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Biological Activity

Penbutolol sulfate is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker. Penbutolol is a sympathomimetic drug,used in the treatment of high blood pressure.

Chemical Information
Molecular Weight 340.47
CAS Number 38363-32-5
Solubility (25°C) Water 5 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Penbutolol

[2] No authors listed. Beta Adrenergic Blocking Agents

[3] No authors listed. Penbutolol

[4] Kevin B Ita, et al. Influence of sonophoresis and chemical penetration enhancers on percutaneous transport of penbutolol sulfate

[5] K B Ita, et al. In vitro transdermal iontophoretic delivery of penbutolol sulfate

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Keywords: Penbutolol sulfate, (-)-Terbuclomine supplier, Adrenergic Receptor, inhibitors, activators


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