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PD 169316

Cat. No. M2583
PD 169316 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 150 In stock
50mg USD 500 In stock
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Quality Control
Biological Activity

PD169316, a p38 MAPK inhibitor. When at 5 μM or higher,it can block TGFβ signaling activity and thus caution must be used when attributing cellular activities exclusively to p38 MAPK signaling when these inhibitors are used experimentally. PD169316 attenuated apoptosis in potassium-deprived cells in a dose dependent manner significantly . PD169316 rescued the inhibitory effect of sphingosine on the formation of inositol phosphates by PGF(2alpha) or NaF in osteoblast-like MC3T3-E1 cells.

Customer Product Validations & Biological Datas
Source Oncol Lett (2018). Figure 7. PD169316
Method CCK‑8 assay
Cell Lines NB4 cells
Concentrations 10 μM
Incubation Time 24 h
Results The results of the CCK‑8 assay showed that PD169316 could partially reverse the growth inhibition induced by lapatinib treatment.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 360.34
Formula C20H13FN4O2
CAS Number 152121-53-4
Purity >99%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells.
Fu Y, et al. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7. PMID: 14521923.

Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons.
Nath R, et al. Cell Mol Biol Lett. 2001;6(2):173-84. PMID: 11544639.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PD 169316 supplier, p38 MAPK, inhibitors

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