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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9013 | R1487 Hydrochloride | R1487 Hydrochloride is an orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. |
| M8991 | Dilmapimod | Dilmapimod (also known as SB-681323 and GW-681323) is a p38 MAPK inhibitor that potentially suppresses inflammation in COPD. |
| M8910 | Pamapimod | Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor, inhibited p38alpha and p38beta enzymatic activity, with IC50 values of 0.014 +/- 0.002 and 0.48 +/- 0.04 microM, respectively. |
| M7582 | SB 239063 | SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. |
| M7558 | SD-06 | SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). IC50 value: 170 nM Target: p38MAPK |
| M7545 | SKF-86002 | SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes. |
| M6146 | TA 02 | TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. IC50 value: 20 nM. TA-02 is a novel compound with similar cardiogenic properties as SB203580 and SB202190. TA-02 especially inhibits TGFBR-2. |
| M5873 | Pexmetinib (ARRY-614) | Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1. |
| M3751 | Losmapimod | Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
| M3294 | VX-745 | VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ. |
| M3048 | TAK-715 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. |
| M3011 | Skepinone-L | Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM. |
| M2583 | PD 169316 | PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor with IC50 = 89 nM. |
| M2318 | LY2228820 | LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM. |
| M2317 | VX-702 | VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM. |
| M2136 | PH-797804 | PH-797804 is a highly selective and potent inhibitor of p38 MAP kinase with IC50 of 26 nM. |
| M2062 | SB 202190 | SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| M1781 | SB203580 | SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3-5 μM. |
| M1675 | BIRB796 | BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM. |
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