Catalog

p38 MAPK P38 mitogen-activated protein kinases

Inhibitors

Cat.No.	Name	Information
M3751	Losmapimod	Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
M3294	VX-745	VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
M3048	TAK-715	TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
M3011	Skepinone-L	Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM.
M2583	PD 169316	PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor with IC50 = 89 nM.
M2318	LY2228820	LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM.
M2317	VX-702	VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM.
M2136	PH-797804	PH-797804 is a highly selective and potent inhibitor of p38 MAP kinase with IC50 of 26 nM.
M2062	SB 202190	SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively.
M1781	SB203580	SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3-5 μM.
M1675	BIRB796	BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM.