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Cat. No. M8991
Dilmapimod Structure

SB-681323; GW-681323

Size Price Availability
5mg USD 1850 1-2 Weeks
10mg USD 3150 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. SB-681323 potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression. Dilmapimod (SB-681323) inhibited TNF-alpha production. The treatment with SB-681832 is a safe and effective means of reducing hsCRP in undergoing elective PCI.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 456.42
Formula C23H19F3N4O3
CAS Number 444606-18-2
Purity >98%
Solubility Soluble in DMSO
Storage at -20°C

A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients.
Singh D, et al. J Clin Pharmacol. 2010 Jan;50(1):94-100. PMID: 19880675.

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Keywords: Dilmapimod, SB-681323; GW-681323 supplier, p38 MAPK, inhibitors

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