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PD 123319 ditrifluoroacetate

Cat. No. M2164
PD 123319 ditrifluoroacetate Structure
Size Price Availability Quantity
10mg USD 145  USD145 In stock
50mg USD 450  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist with IC50 values of 34 and 210 nM in rat adrenal tissue and brain respectively. PD 123319 ditrifluoroacetate prevents the binding of angiotensin II to the receptor, which blocks signal transduction and causes vasodilation. Intravenous administration of PD 123319 to conscious hypertensive rats elicited an immediate dose-dependent increase in MAP that was sustained for approximately 7.4 min with 3 mg/kg PD123319.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 736.67
Formula C31H32N4O3.2CF3CO2H
CAS Number 136676-91-0
Purity >98%
Solubility Water
Storage at -20°C
References

[1] Tamura M, et al. J Hypertens. Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats.

[2] Park PD, et al. Eur J Pharmacol. Receptor subtypes mediating spinal cardiovascular effects of angiotensin II in rat using losartan and PD 123319.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PD 123319 ditrifluoroacetate supplier, Angiotensin Receptor, inhibitors

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