PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist with IC50 values of 34 and 210 nM in rat adrenal tissue and brain respectively. PD 123319 ditrifluoroacetate prevents the binding of angiotensin II to the receptor, which blocks signal transduction and causes vasodilation. Intravenous administration of PD 123319 to conscious hypertensive rats elicited an immediate dose-dependent increase in MAP that was sustained for approximately 7.4 min with 3 mg/kg PD123319.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Angiotensin Receptor Products|
|C-Type Natriuretic Peptide (CNP) (1-22), human
C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide.
AVE 0991 is an orally active agonist of angiotensin-(1-7) receptor with IC50 of 21 nM.
TRV-120027 (also known as TRV027) is an angiotensin II receptor type 1 (AT1R) antagonist and engages ß-arrestins while blocking G-protein signaling.
BIBS39 is a new nonpeptide angiotensin II (AII) receptor antagonist.
A-779 is a specific antagonist of G-protein coupled receptor (Mas receptor).
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