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Cat. No. M3930
Parthenolide Structure


Size Price Availability Quantity
50mg USD 60 In stock
100mg USD 90 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Parthenolide inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. Parthenolide has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide. COX-2 inhibition is the mechanism by which parthenolide induces cell death in the cancer stem-like cells of nasopharyngeal carcinoma. In addition, parthenolide exhibited an inhibitory effect on nuclear factor-kappa B (NF-κB) nucler translocation by suppressing both the phosphorylation of IκB kinase complex and IκBα degradation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 248.32
Formula C15H20O3
CAS Number 20554-84-1
Purity >98%
Solubility DMSO 100 mg/mL
Storage at -20°C

Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-κB/COX-2 pathway.
Liao K, et al. Theranostics. 2015 Jan 1;5(3):302-21. PMID: 25553117.

Parthenolide induces autophagy via the depletion of 4E-BP1.
Lan B Biochem Biophys Res Commun. 2015 Jan 2;456(1):434-9. PMID: 25482447.

Effect of parthenolide on growth and apoptosis regulatory genes of human cancer cell lines.
Al-Fatlawi AA, et al. Pharm Biol. 2015 Jan;53(1):104-9. PMID: 25289524.

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Abmole Inhibitor Catalog 2017

Keywords: Parthenolide, (-)-Parthenolide supplier, NF-κB, inhibitors

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