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Paroxetine HCl

Cat. No. M5861
Paroxetine HCl Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM/1mL In DMSO USD 110 In stock
100mg USD 100 In stock
500mg USD 200 In stock
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Quality Control
Biological Activity

Paroxetine HCl is an antidepressant drug of the SSRI type.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 365.83
Formula C19H20FNO3.HCl
CAS Number 78246-49-8
Purity 99.69%
Solubility 73 mg/mL in DMSO
Storage at -20°C
References

Generation of hydrate forms of paroxetine HCl from the amorphous state: an evaluation of thermodynamic and experimental predictive approaches.
Pina MF, et al. Int J Pharm. 2015 Mar 15;481(1-2):114-24. PMID: 25592956.

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