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Panitumumab

Cat. No. M1503
Panitumumab Structure
Synonym:

ABX-EGF

Size Price Availability Quantity
2mg USD 600  USD600 In stock
5mg USD 900  USD900 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Panitumumab is a fully human IgG2 monoclonal antibody specific to the epidermal growth factor receptor (EGFR). Panitumumab works by binding to the extracellular domain of the EGFR preventing its activation. This results in halting of the cascade of intracellular signals dependent on this receptor. The pharmacokinetics (PK) of panitumumab shows the so-called target-mediated disposition behavior.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 144321.76
Formula C6398H9878N1694O2016S48
CAS Number 339177-26-3
Purity >99%
Solubility
Storage -80°C for long term
References

[1] Douillard JY, et al. N Engl J Med. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer.

[2] Wells A Messersmith, et al. Clin Cancer Res . Panitumumab, a monoclonal anti epidermal growth factor receptor antibody in colorectal cancer: another one or the one?

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Keywords: Panitumumab, ABX-EGF supplier, EGFR/HER2, inhibitors

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