Free shipping on all orders over $ 500


Cat. No. M9102
Palosuran Structure


Size Price Availability Quantity
2mg USD 210 In stock
5mg USD 275 In stock
10mg USD 430 In stock
25mg USD 770 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. On cells, the inhibitory binding potency of palosuran against human UT receptor was lower than on membranes (IC50 = 46.2 ± 13 nM on TE 671 cells and 86 ± 30 nM on recombinant CHO cells).

Long-term treatment of streptozotocin-induced diabetic rats with palosuran improved survival, increased insulin, and slowed the increase in glycemia, glycosylated hemoglobin, and serum lipids. In mesenteric vessels, palosuran treatment up-regulated expression of RhoA and Rho-kinase, increased Rho-kinase-activity, and diminished nitric oxide (NO)/cyclic guanosine 3',5'-monophosphate (cGMP) signaling. Moreover, palosuran increased renal blood flow, sodium, and water excretion in BDL rats.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 418.53
Formula C25H30N4O2
CAS Number 540769-28-6
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C

Palosuran treatment effective as bosentan in the treatment model of pulmonary arterial hypertension.
Pehlivan Y, et al. Inflammation. 2014 Aug;37(4):1280-8. PMID: 24604341.

Urotensin inhibition with palosuran could be a promising alternative in pulmonary arterial hypertension.
Onat AM, et al. Inflammation. 2013 Apr;36(2):405-12. PMID: 23100033.

Pharmacokinetics and pharmacodynamics of the urotensin-II receptor antagonist palosuran in healthy male subjects.
Sidharta PN, et al. J Clin Pharmacol. 2009 Oct;49(10):1168-75. PMID: 19625629.

Related Products

S107 is a Type 1 ryanodine receptor (RyR1) stabilizer.


3,3’,5,5’-Tetramethylbenzidine(TMB) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).


Coelenterazine is the luciferin, the light-emitting molecule, used for monitoring reporter genes in BRET, ELISA and HTS techniques.


Fluorescein is a synthetic organic compound and dye.


SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.

Abmole Inhibitor Catalog 2017

Keywords: Palosuran, ACT-058362 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.