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Palmitone

Cat. No. M16992
Palmitone Structure
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Biological Activity

Palmitone

Chemical Information
CAS Number 502-73-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Swastika, et al. Int J Pharm. Evaluation of BBB permeable nucleolipid (NL DPU): A di-C15-ketalised palmitone appended uridine as neuro-tracer for SPECT

[2] E Cano-Europa, et al. Neurosci Lett. Palmitone prevents pentylenetetrazole-caused neuronal damage in the CA3 hippocampal region of prepubertal rats

[3] Ma Eva Gonzlez-Trujano, et al. Epilepsy Behav. Effect of repeated administration of Annona diversifolia Saff. (ilama) extracts and palmitone on rat amygdala kindling

[4] Ma Eva Gonzlez-Trujano, et al. Epilepsia. Anticonvulsant effect of Annona diversifolia Saff. and palmitone on penicillin-induced convulsive activity. A behavioral and EEG study in rats

[5] Ma Eva Gonzlez-Trujano, et al. Planta Med. Palmitone isolated from Annona diversifolia induces an anxiolytic-like effect in mice

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