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Pacritinib

Cat. No. M2912
Pacritinib  Structure
Size Price Availability Quantity
5mg USD 240 In stock
50mg USD 1600 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 472.58
Formula C28H32N4O3
CAS Number 937272-79-2
Purity >99%
Solubility DMSO
Storage at -20°C
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Oclacitinib maleate

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Baricitinib phosphate

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JANEX-1

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Decernotinib

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pacritinib supplier, JAK, inhibitors

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