Paclobutrazol is a new, high-efficiency, low-toxicity plant growth regulator that can inhibit the production of gibberellin derivatives and reduce the division and elongation of plant cells. Paclobutrazol is easily absorbed by roots, stems, and leaves, and is conducted through the xylem of the plant. Paclobutrazol also has a bactericidal effect. Paclobutrazol has a wide range of activities on gramineous plants, which can make the plant stem internodes stout, reduce lodging and increase yield.
| Molecular Weight | 293.79 |
| Formula | C15H20ClN3O |
| CAS Number | 76738-62-0 |
| Form | Solid |
| Solubility (25°C) | Methanol ≥ 50 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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