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Oteseconazole

Cat. No. M10444
Oteseconazole Structure
Synonym:

VT-1161

Size Price Availability Quantity
1mg USD 120  USD120 In stock
5mg USD 240  USD240 In stock
10mg USD 360  USD360 In stock
50mg USD 960  USD960 In stock
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Quality Control & Documentation
Biological Activity

Oteseconazole (VT-1161) is an antifungal compound with oral activity that is highly selective for CYP51. It can effectively bind to and inhibit CYP51 of N. albicans (Kd <39 nM), but shows no obvious effect on human CYP51.

Chemical Information
Molecular Weight 527.39
Formula C23H16F7N5O2
CAS Number 1340593-59-0
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] E P Garvey, et al. Antimicrob Agents Chemother. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model

[2] A G S Warrilow, et al. Antimicrob Agents Chemother. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme

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