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Ostarine

Cat. No. M1973
Ostarine Structure
Synonym:

MK-2866, GTx-024

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 200 In stock
50mg USD 600 In stock
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Quality Control
Biological Activity

Ostarine (MK-2866) is a selective androgen receptor modulator (SARM) with anabolic activity. Ostarine (MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio remaining in the low risk category. Ostarine exhibits significantly androgenic and anabolic activity by stimulating the growth of prostate, seminal vesicles, and levator ani muscle when administered in castrated male rats. Ostarine is more potent than other cyano/nitro group-substituted SARMs. Ostarine exhibits the highest in vivo androgenic and anabolic activity of any AR nonsteroidal agonist examined to date, with ED50 values of 0.12, 0.39 and 0.03 mg/day in prostate, seminal vesicles, and levator ani muscle, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 389.33
Formula C19H14F3N3O3
CAS Number 841205-47-8
Purity >99%
Solubility DMSO 70 mg/mL
Ethanol 70 mg/mL
Storage at -20°C
References

Recent advances in the development of selective androgen receptor modulators.
Zhang X, et al. Expert Opin Ther Pat. 2009 Sep;19(9):1239-58. PMID: 19505196.

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.
Mohler ML, et al. J Med Chem. 2009 Jun 25;52(12):3597-617. PMID: 19432422.

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Keywords: Ostarine, MK-2866, GTx-024 supplier, Androgen Receptor, inhibitors

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