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Oritavancin diphosphate

Cat. No. M6133
Oritavancin diphosphate  Structure

LY 333328 diphosphate

Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 260 In stock
50mg USD 1050 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In vitro testing indicates that oritavancin has synergistic effects against some strains of S. aureus when given with gentamicin, linezolid, or rifampicin (mixed results); against E. faecium (vancomycin intermediate and vancomycin resistant) when given with ampicillin, ciprofloxacin, gentamicin, or daptomycin; and against multidrug-resistant Acinetobacter baumannii when given with colistin.36–42 Moxifloxacin showed variable results.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1989.09
Formula C86H97Cl3N10O26.2(H3PO4)
CAS Number 192564-14-0
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C

Oritavancin diphosphate.
Cada DJ, et al. Hosp Pharm. 2014 Dec;49(11):1049-60. PMID: 25673895.

Oritavancin - a new semisynthetic lipoglycopeptide agent to tackle the challenge of resistant gram positive pathogens.
Das B, et al. Pak J Pharm Sci. 2013 Sep;26(5):1045-55. PMID: 24035967.

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