In vitro testing indicates that oritavancin has synergistic effects against some strains of S. aureus when given with gentamicin, linezolid, or rifampicin (mixed results); against E. faecium (vancomycin intermediate and vancomycin resistant) when given with ampicillin, ciprofloxacin, gentamicin, or daptomycin; and against multidrug-resistant Acinetobacter baumannii when given with colistin.36–42 Moxifloxacin showed variable results.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
Cada DJ, et al. Hosp Pharm. 2014 Dec;49(11):1049-60. PMID: 25673895.
Oritavancin - a new semisynthetic lipoglycopeptide agent to tackle the challenge of resistant gram positive pathogens.
Das B, et al. Pak J Pharm Sci. 2013 Sep;26(5):1045-55. PMID: 24035967.
Propofol inhibited tumor size, cell viability and promoted cell apoptosis via inhibiting mTOR/p70S6K pathway mediated by HOTAIR in cervical cancer.
Propacetamol is water soluble and can be directly injected.
Cetilistat is an inhibitor of pancreatic and gastrointestinal lipases. It has great treatment of obesity in both diabetic and non-diabetic patients.
|Calcium-Sensing Receptor Antagonists I
Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors.
AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
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