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Synonym: LY 333328 diphosphate
In vitro testing indicates that oritavancin has synergistic effects against some strains of S. aureus when given with gentamicin, linezolid, or rifampicin (mixed results); against E. faecium (vancomycin intermediate and vancomycin resistant) when given with ampicillin, ciprofloxacin, gentamicin, or daptomycin; and against multidrug-resistant Acinetobacter baumannii when given with colistin.36–42 Moxifloxacin showed variable results.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 1989.09 |
| Formula | C86H97Cl3N10O26.2(H3PO4) |
| CAS Number | 192564-14-0 |
| Purity | >99% |
| Solubility | 10 mM in DMSO |
| Storage | at -20°C |
Oritavancin diphosphate.
Cada DJ, et al. Hosp Pharm. 2014 Dec;49(11):1049-60. PMID: 25673895.
Oritavancin - a new semisynthetic lipoglycopeptide agent to tackle the challenge of resistant gram positive pathogens.
Das B, et al. Pak J Pharm Sci. 2013 Sep;26(5):1045-55. PMID: 24035967.
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