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Olodaterol hydrochloride

Cat. No. M13897
Olodaterol hydrochloride Structure
Synonym:

BI1744 hydrochloride

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 422.9
Formula
CAS Number 869477-96-3
Purity >99%
Solubility Water 150 mg/mL
Storage 2-8°C, dry, sealed
References

[1] No authors listed. Clinical Review Report: tiotropium bromide monohydrate and olodaterol hydrochloride (Inspiolto Respimat) for oral inhalation [Internet]

[2] No authors listed. Pharmacoeconomic Review Report: Tiotropium bromide monohydrate and olodaterol hydrochloride (Inspiolto Respimat) for oral inhalation [Internet]

[3] Mnica Aparici, et al. Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β 2-adrenoceptor agonist (MABA) molecule

[4] Daniel A Hussar, et al. New drugs: dulaglutide, olodaterol hydrochloride, and vorapaxar sulfate

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