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Obinutuzumab

Cat. No. M1615
Obinutuzumab Structure
Synonym:

afutuzumab; GA101

Size Price Availability Quantity
2mg USD 530  USD530 In stock
5mg USD 780  USD780 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Obinutuzumab (GA101) is a fully humanized monoclonal antibody that binds to an epitope on CD20. Obinutuzumab binds to CD20 on B cells and causes these cells to be destroyed by engaging the adaptive immune system, directly activating intracellular apoptosis pathways, and activating the complement system.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 146062.27
Formula C6512H10060N1712O2020S44
CAS Number 949142-50-1
Purity >98%
Solubility
Storage -80°C for long term
References

[1] Evans SS, et al. J Adv Pract Oncol. Obinutuzumab: A Novel Anti-CD20 Monoclonal Antibody for Chronic Lymphocytic Leukemia.

[2] Herting F, et al. Leuk Lymphoma. Enhanced anti-tumor activity of the glycoengineered type II CD20 antibody obinutuzumab (GA101) in combination with chemotherapy in xenograft models of human lymphoma.

[3] Decaup E, et al. Blood Cancer J. Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model.

[4] Herter S, et al. Mol Cancer Ther. Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models.

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Keywords: Obinutuzumab, afutuzumab; GA101 supplier, inhibitors

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