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NVP-TAE226

Cat. No. M2301
NVP-TAE226 Structure
Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 180 In stock
50mg USD 700 In stock
100mg USD 1200 In stock
200mg USD 1580 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

NVP-TAE226, a potent dual FAK/IGF-1R, inhibiting FAK and IGF-1R with IC50 of 5.5 nM and 0.14 μM, respectively.

Protocol
Cell Experiment
Cell lines U87, U87 EGFR, U87 vIII and U251 cells
Preparation method Cell Viability Assay
Cell cultures were harvested with 0.05% trypsin and seeded in triplicate at 2 × 104 in 24-well culture plates for 24 h before drug treatment. Culture medium was used for mock treatment. Cells were harvested at the indicated day after treatment, and viable cells were counted using the Vi-cell viability analyzer.
Concentrations 1 and 10 μmol/L
Incubation time 1, 3 and 5 days
Animal Experiment
Animal models U87 and LN229 glioma xenograft Intracranial Animal Model
Formulation 0.5% methylcellulose
Dosages 50 or 75 mg/kg once a day for 5 days and off for 2 days, for a duration of 4 weeks
Administration oral gavage
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 468.94
Formula C23H25ClN6O3
CAS Number 761437-28-9
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
References

Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.
Liu TJ, et al. Mol Cancer Ther. 2007 Apr;6(4):1357-67. PMID: 17431114.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: NVP-TAE226 supplier, FAK, inhibitors

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