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NSC228155

Cat. No. M9709
NSC228155 Structure
Synonym:

NSC-228155

Size Price Availability
50mg USD 250  USD250 4-7 Days
100mg USD 380  USD380 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

NSC228155 is an activator of EGFR, which binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 290.25
Formula C11H6N4O4S
CAS Number 113104-25-9
Purity >98.5%
Solubility DMSO ≥ 15 mg/mL
Storage at -20°C
References

[1] Vehary Sakanyan, et al. Sci Rep. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1

[2] Vehary Sakanyan, et al. Sci Rep. Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells

[3] Fuchun Xie, et al. Bioorg Med Chem Lett. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription

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