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NS 3763

Cat. No. M7050

All AbMole products are for research use only, cannot be used for human consumption.

NS 3763 Structure

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Quality Control & Documentation
Biological Activity

NS 3763 is a selective non-competitive kainate receptor antagonist; displays selectivity for GLUK5 subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).

Chemical Information
Molecular Weight 404.38
Formula C22H16N2O6
CAS Number 70553-45-6
Solubility (25°C) DMSO 10.11 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gkogkas, et al. Nature. Autism-related deficits via dysregulated eIF4E-dependent translational control.

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