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NS-1619

Cat. No. M5072
NS-1619 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 95  USD95 In stock
5mg USD 85  USD85 In stock
10mg USD 108  USD108 In stock
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Quality Control & Documentation
Biological Activity

NS-1619 induced concentration-dependent activation of BKCa channels with a calculated EC50 of 32 microM. The NS 1619-induced activity was dependent on the presence of free Ca2+ at the intracellular surface, but was not associated with a change in channel voltage sensitivity.NS 1619 (50 microM) inhibited the noradrenaline-induced contraction. NS 1619 (10-100 microM) reduced the high K+-induced contractions in a noncompetitive manner.

Chemical Information
Molecular Weight 362.23
Formula C15H8F6N2O2
CAS Number 153587-01-0
Form Solid
Solubility (25°C) DMSO 5.3 mg/ml
Water < 1 mg/ml
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Huang Y,et.al. Eur J Pharmacol. NS 1619 activates Ca2+-activated K+ currents in rat vas deferens.

[2] Lee K,et.al. Eur J Pharmacol. NS 1619 activates BKCa channel activity in rat cortical neurones.

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