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NQDI-1

Cat. No. M5215
NQDI-1 Structure
Size Price Availability Quantity
5mg USD 75 In stock
10mg USD 110 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

NQDI-1 is an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death. NQDI-1 at 30 μM almost completely and 50 μM completely prevented ASK1, JNK and p38 phosphorylation. 30 μM NQDI-1 was sufficient to increase bone volume 64% above control (P=0.04), which was comparable to the 82% increase observed in the KO.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 319.31
Formula C19H13NO4
CAS Number 175026-96-7
Purity >99%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival.
Eaton GJ, et al. Cell Death Dis. 2014 Nov 13;5:e1522. PMID: 25393478.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: NQDI-1 supplier, Caspase, inhibitors

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