NQDI-1 is an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death. NQDI-1 at 30 μM almost completely and 50 μM completely prevented ASK1, JNK and p38 phosphorylation. 30 μM NQDI-1 was sufficient to increase bone volume 64% above control (P=0.04), which was comparable to the 82% increase observed in the KO.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 20 mg/mL|
Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival.
Eaton GJ, et al. Cell Death Dis. 2014 Nov 13;5:e1522. PMID: 25393478.
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