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NP603

Cat. No. M7954

All AbMole products are for research use only, cannot be used for human consumption.

NP603 Structure

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Quality Control & Documentation
Biological Activity

NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket. NP603 is a very weak inhibitor of EGFR (IC50 >100 μM).

Chemical Information
Molecular Weight 446.5
Formula C26H26N2O5
CAS Number 949164-80-1
Solubility (25°C) DMSO: ≥30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nan Lin, et al. NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats

[2] Naparat Kammasud, et al. Novel inhibitor for fibroblast growth factor receptor tyrosine kinase

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Keywords: NP603 supplier, inhibitors, activators

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