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Norpterosin B glucoside

Cat. No. M17500
Norpterosin B glucoside Structure
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Biological Activity

Norpterosin B glucoside

Chemical Information
CAS Number 1226785-88-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stefan D Anker, et al. Circulation. Kidney Function After Initiation and Discontinuation of Empagliflozin in Patients With Heart Failure With and Without Type 2 Diabetes: Insights From the EMPERIAL Trials

[2] Jun-Sheng Zhang, et al. Chin J Nat Med. Lignans with NO inhibitory activity from Tinospora sinensis

[3] Koenraad Philippaert, et al. Circulation. Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin

[4] Michel Boni Bitchi, et al. Nat Prod Res. New Oleanane-type glycosides and secoiridoid glucoside from Aptandra zenkeri

[5] Nicole Bajcsik, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Simultaneous determination of cucurbitacin B, E, I and E-glucoside in plant material and body fluids by HPLC-MS

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