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Norethindrone

Cat. No. M2887
Norethindrone Structure
Synonym:

Norethisterone

Size Price Availability Quantity
100mg USD 58  USD58 In stock
500mg USD 90  USD90 In stock
1g USD 135  USD135 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.

Customer Product Validations & Biological Datas
Source J Clin Pharmacol (2012). Figure 1. Norethindrone
Method PK and Pharmacodynamic (PD) Assessments
Cell Lines
Concentrations 0.5 mg/kg
Incubation Time 1, 7, 14, 21, 22, 28, 35, 42, 49, 50, and 56 days
Results Mean steady-state Cmax, AUC, and Cmin and their 90% CIs of their GLSMRs fell within the no-effect limit boundary of 0.80 to 1.25.
Protocol
Cell Experiment
Cell lines Human epithelial cervical cancer cells
Preparation method Thereafter, the cells were incubated with serum-free, phenol-free DMEM for 2 hrs, before treatment with 100 nM DEX, MPA, P4 and NET-A for 1 hr. Cells were crosslinked for 10 min at 37°C with1% formaldehyde and the reaction was stopped with 0.1 mM glycine for 5 min, shaking at room temperature.
Concentrations 100 nM
Incubation time 1 h
Animal Experiment
Animal models Female Sprague-Dawley rats
Formulation corn oil
Dosages 3 μg/rat/day
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 298.42
Formula C20H26O2
CAS Number 68-22-4
Purity >98%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

[1] Africander DJ, et al. J Steroid Biochem Mol Biol. A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A).

[2] Govender Y, et al. PLoS One. The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the glucocorticoid receptor.

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Keywords: Norethindrone, Norethisterone supplier, inhibitors

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