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Norepinephrine hydrochloride

Cat. No. M13896
Norepinephrine hydrochloride Structure
Synonym:

Levarterenol hydrochloride; L-Noradrenaline hydrochloride

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 205.64
Formula
CAS Number 329-56-6
Purity >99%
Solubility Water 90 mg/mL
DMSO 44 mg/mL
Storage 2-8°C, dry, sealed
References

[1] T Yadav, et al. Structural confirmation and spectroscopic study of a biomolecule: Norepinephrine

[2] Maedeh Ghasemi, et al. Mechanisms underlying anticonvulsant and proconvulsant actions of norepinephrine

[3] May T Aziz, et al. Serotonin-norepinephrine reuptake inhibitors for the management of chemotherapy-induced peripheral neuropathy

[4] Eliyahu Dremencov, et al. Brain norepinephrine system as a target for antidepressant and mood stabilizing medications

[5] N Weiner. Regulation of norepinephrine biosynthesis

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Keywords: Norepinephrine hydrochloride, Levarterenol hydrochloride; L-Noradrenaline hydrochloride supplier, Adrenergic Receptor, inhibitors

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